Psilocybin or magic mushrooms are naturally occurring and are consumed for their hallucinogenic effects. They belong to a group of drugs known as psychedelics, because of the changes experienced to perception, mood and thought. The key ingredient found in magic mushrooms is psilocybin.
Depression is among the most researched indications for psilocybin therapy. As Healthline previously reported last year, psilocybin therapy was given “breakthrough therapy” designation (a review fast track) by the FDA for the treatment of depression.
The Usona Institute, a psychedelic research center, is currently in the planning stages of their phase III trial, which will likely begin this year.
In a small pilot study from Johns Hopkins UniversityTrusted Source, researchers found that psilocybin therapy significantly improved abstaining from smoking over a 12-month follow-up period.
Matthew Johnson, PhD, associate professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine, led that study.
According to him, psilocybin also has potential to treat other substance use disorders, including alcohol and cocaine addiction.
“The general idea is that the nature of these disorders is a narrowed mental and behavioral repertoire,” he told Healthline. “So, [psilocybin] in well-orchestrated sessions [has] the ability to essentially shake someone out of their routine to give a glimpse of a larger picture and create a mental plasticity with which people can step outside of those problems.”
In fact, a small open-label studyTrusted Source on psilocybin and alcohol dependence found that following treatment, both drinking and heavy drinking declined.